I have been running for nearly 40 years. It is my primary form of exercise unless weather conditions dictate that I exercise indoors. Then I go for my Precor 546 elliptical trainer. I used to be much hardier when I was younger and used to run outside no matter what the condition. Now I will rarely run outside if the temperature is below freezing, if it is dark or if it is raining. I have broken a number of bones in my life by running in "unsafe" condtions and I have read of too many people being killed because they were hit by a car at night, so I now chose safer condtions.
Another reason I find running so useful is that it is highly efficient and I can maximize my time efficiency with it. I also happened to be reasonably good at it when I was younger and have run a 2:50 marathon when I was in medical school and on the University of Chicago Track Club.
However, it is important to understand that just because I find running personally useful that does not mean most people should do it. Quite the contrary. In fact nearly anyone with a knee injury is asking for trouble if they choose running as their primary exercise. Additionally, obese individuals typically have higher risks of injury with running so elliptical trainers are a far better option.
I found this article on how running differentiates us from the apes quite fascinating and thought many would enjoy it.
Some Anatomical Features That Help Humans Run
Medi Lexicon November 18, 2004