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Popular Diabetes Drugs Associated with Fractures

Postmenopausal women with diabetes taking thiazolidinediones (TZDs), such as rosiglitazone and pioglitazone, may be at increased risk for fractures. Men with diabetes taking both loop diuretics and TZDs may also be at increased risk.

Researchers conducted a matched case-control study to assess the odds of TZD exposure in patients with type 2 diabetes with and without fractures. Women aged 50 years and older with fractures were significantly more likely to have filled prescriptions for TZDs. Men with fractures were more likely to have filled prescriptions for TZDs and loop diuretics.

According to Newswise:

“This result is particularly interesting because in men, loop diuretics or TZDs alone did not confer significant risks.”

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