Western Diet Exacerbates Sepsis

The typical “Western” diet causes a dramatic immune system overreaction to sepsis, a condition of systemic bacterial infection. An experimental study in mice shows that a diet high in sugar and fat greatly exaggerates the inflammatory response to sepsis.

Mortality resulting from sepsis in morbidly obese subjects is estimated to be 7 times that of sepsis mortality in lean individuals.

Science Daily reports:

“Mice on [a] western diet ... showed exacerbated inflammation that was found to be mediated by signaling via the toll-like receptor 4 (TLR-4) pathway.”

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