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Antipsychotics for Schizophrenia Associated with Loss in Brain Volume

Patients with schizophrenia who take antipsychotic medications appear to lose a measurable amount of brain tissue over time.

Progressive changes in brain volume had been observed in patients with schizophrenia before, but were thought to be an effect of the disease. Recent animal studies indicate that antipsychotics may also contribute to brain tissue volume loss.

Science Daily reports:

"Patients who were followed for longer periods of time experienced more reductions in brain volume ... More intense antipsychotic treatment was associated with overall measures of brain tissue loss, smaller gray matter volume and progressive declines in white matter volume."

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