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Breeding Nicotine Addiction To Conquer It

  • November 11, 2004

To study the effects of nicotine addiction and related behaviors, a research team funded by the National Institute on Drug Abuse (NIDA) created a special strain of mice through a process in which researchers altered only one amino acid. This "knock-in" technology made this particular strain of mice exceptionally sensitive to nicotine. Researchers found these mice display rather powerful addiction-related behaviors, including reward, tolerance and sensitization to the drug, that occur...