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Animals Used as Subjects to Test Opioid Overdose Vaccines

Human clinical trials for vaccines that prevent heroin and fentanyl overdoses are set to begin in early 2024 — following preclinical data from animal-based trials. These results originated from early safety trials on animal models that were established as “safe enough” to proceed with testing on humans. The vaccine is designed to neutralize the target opioid with assistance from an ingredient called INI-4001, which is an adjuvant intended to improve the vaccine response....

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