Chronic low back pain is a leading disability worldwide, with lumbar degenerative spondylolisthesis (LDS) being a common cause, particularly in adults over 50, especially women. LDS happens when the spinal discs and joints wear down, causing the bones in the spine to shift, which often leads to pain and movement issues. This condition can require surgery for relief.
Factors like arthritis, weakened ligaments, and reduced disc space also worsen LDS, making it harder to manage and increasing the chances of discomfort and limited mobility.
A recent study looked at how gut health might affect spinal health, specifically its connection to lumbar degenerative spondylolisthesis (LDS). Researchers analyzed data from 51 patients who had lumbar spine surgery, comparing those with LDS to those without.
By examining spinal images and gut bacteria through DNA sequencing, they found that an imbalance in gut bacteria, called gut dysbiosis, may promote inflammation, which could contribute to LDS. The study showed that the types and diversity of gut bacteria were significantly different between people with and without LDS.
Results showed that people with LDS had a more varied mix of gut bacteria and higher levels of bacteria linked to inflammation. Specific bacteria, like the inflammation-promoting Dialister, were more common in LDS patients, while beneficial, anti-inflammatory types like Slackia were reduced.
These findings suggest that imbalances in gut bacteria may contribute to spinal degeneration, offering a promising area for future research on how gut health could support managing chronic spinal conditions.
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