A new study suggests that one of the most common diabetes drugs may reduce some of the benefits of exercise. Researchers found that metformin, a medication widely used to control blood sugar, might limit improvements in blood vessel health, physical fitness, and glucose control — all key benefits usually gained from regular exercise.
In the 16-week study, adults at risk for metabolic syndrome took part in either high- or low-intensity exercise programs, with or without metformin. Those who exercised without the drug showed better blood flow, stronger blood sugar control, and higher aerobic capacity. But those who took metformin had smaller gains and fewer anti-inflammatory benefits from their workouts.
Scientists think metformin may interfere with how mitochondria — the cell’s energy centers — respond to exercise. These findings don’t mean people should stop taking metformin or stop exercising, but they do suggest that the drug and exercise may interact in complex ways. Experts recommend that people on metformin talk with their doctors about their exercise routines and monitor their blood sugar levels closely to make sure they’re getting the best results from both.
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