A new study suggests a protein called Reelin could help treat both gut barrier problems and severe depression. Researchers found that chronic stress can damage the gut lining, allowing bacteria and toxins to leak into the bloodstream. This process, often called “leaky gut,” may trigger inflammation that worsens depressive symptoms.
In early testing, chronic stress reduced Reelin levels in the gut. When researchers restored Reelin with a single treatment, the gut lining showed less damage and better repair. The findings build on earlier studies showing that people with major depression often have lower Reelin levels in the brain, where the protein helps regulate mood and stress responses.
The results suggest Reelin may protect the gut barrier and calm inflammation linked to stress and depression. While this research is still early and not yet tested in people, it highlights the growing understanding that gut health and brain health are closely connected. Scientists say targeting both systems together may lead to new approaches for treating depression in the future.
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