Many people think over-the-counter painkillers are harmless, but some can raise heart risk in certain people. NSAIDs, such as ibuprofen, naproxen, and diclofenac, have been linked to higher blood pressure, heart attacks, and strokes. The risk is higher when these drugs are used often or at high doses. They can cause the body to hold onto salt and fluid, which makes the heart work harder.
The risks vary by drug. Ibuprofen is more likely to raise blood pressure. Diclofenac carries the highest overall heart risk. Naproxen may be safer than the others, but it still carries some risk. Aspirin is different. Low-dose aspirin is sometimes used to prevent blood clots, but higher doses can cause bleeding and blood pressure problems.
People with heart disease, high blood pressure, diabetes, kidney disease, or a history of stroke face the greatest risk. Adults over 75 are also more vulnerable. Chest pain, shortness of breath, sudden weakness, severe headache, or vision changes require immediate medical care. For safer pain relief, some people may benefit from acetaminophen in moderation, topical treatments, or non-drug options like heat, ice, and physical therapy.
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