Do Antidepressants Make Bones Brittle?

Older adults who take a prescribed antidepressant are at increased risk for bone fractures, according to a growing number of studies.

In one of the latest reports, antidepressants were linked to an increased risk of fractures of the spine and other sites. Women on antidepressants had a 30 percent increased risk of spine fracture, and a 20 percent increased risk of any type of fracture.

Serotonin, a brain chemical linked to depression, is also involved in the physiology of bone. If you alter serotonin levels with a drug, it can result in low bone density, boosting fracture risk.

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